Southeast Ohio Vacations

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Your Southeast Ohio Vacation

Choose a vacation package to Southeast Ohio and make planning your getaway quick and easy. With the logistics arranged before you depart, you can focus on enjoying every second in this destination. Begin your trip to Southeast Ohio with some time in Clarksville visiting popular sights like KFC Yum Center and Kentucky Kingdom. Athens is another city that lures crowds from far and wide. Fun Barn and Strouds Run State Park are two of the top places to see in this destination. Expedia is a one-stop shop for planning your Southeast Ohio vacation. From accommodations and flights, to car rentals and activities, we know how to create a travel experience like no other.

Discover the most popular places to visit in Southeast Ohio

Southeast Ohio Hotel Deals

Ohio University Inn & Conference Center

Ohio University Inn & Conference Center

3.5 out of 5
331 Richland Ave, Athens, OH
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $141 total per night from Nov 2 to Nov 3
$141 total
Nov 2 - Nov 3
Total with taxes and fees
9/10 Wonderful! (1,030 reviews)
"Clean room, great restaurant and bar and most importantly easy walk to campus and Court Street"

Reviewed on Sep 30, 2025

Ohio University Inn & Conference Center
Days Inn by Wyndham Columbus East Airport

Days Inn by Wyndham Columbus East Airport

2.5 out of 5
2100 Brice Road, Reynoldsburg, OH
$69 nightly
The price is $82 total per night from Nov 2 to Nov 3
$82 total
Nov 2 - Nov 3
Total with taxes and fees
7/10 Good! (1,024 reviews)
"Ok"

Reviewed on Sep 29, 2025

Days Inn by Wyndham Columbus East Airport
Christopher Inn and Suites

Christopher Inn and Suites

2.5 out of 5
30 North Plaza Boulevard, Chillicothe, OH
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from Nov 3 to Nov 4
$146 total
Nov 3 - Nov 4
Total with taxes and fees
9/10 Wonderful! (1,033 reviews)
"Our room was clean and comfortable. The staff were friendly. The location was convenient for us, and there are plenty of dining options in the area."

Reviewed on Sep 27, 2025

Christopher Inn and Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Southeast Ohio Essential Information

Language
English
Currency
U.S dollars
Closest Airport
John Glenn Columbus Intl. Airport (CMH)

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.